Exploring the piezoelectric phenomenon: From polymers to human tissues and advanced applications in tissue engineering
Martins L., Barbosa AI., Correlo VM., Bhattacharya M., Reis RL.
Narrative Review, published in Bioact Mater (2026) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Bioact Mater (2026)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 41323207
- PMCID
- PMC12664660
- DOI
- 10.1016/j.bioactmat.2025.11.010
- Citations
- 6
Abstract (original English)
Piezoelectricity refers to the phenomenon in which certain materials convert mechanical energy into electrical energy and vice versa. It occurs in natural and synthetic materials, underscoring its broad importance within biological environments. This review will discuss the basic principles of piezoelectricity, with a focus on its presence in synthetic materials, including polymers like polyvinylidene fluoride and other polyesters, along with composites of these polymers. The review will also highlight the natural piezoelectric responses observed in human tissues, including bone, skin, dental tissues, and connective tissues and relate these effects to their non-centrosymmetric molecular structure. Traditional tissue engineering materials focus primarily on biochemical, mechanical signals without sustaining the complexity of a natural microenvironment. Piezoelectric materials may offer a new approach to tissue engineering, providing electrical signals capable of directing cellular behavior. These mechanical generated signals are able to create a dynamic and self-powered method for enhancing cellular communication, survival, and differentiation, particularly applicable to regenerative strategies in bone and neural tissue. The review will also consider the most recent discoveries around the use of piezoelectric materials in the scaffolding systems supporting the growth of bone and
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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