Exploring the role of strontium-based nanoparticles in modulating bone regeneration and antimicrobial resistance: a public health perspective

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Strontium-based nanoparticles (SrNPs) have emerged as a versatile and promising class of nanomaterials with a wide range of potential applications in healthcare, particularly in the fields of bone regeneration and combating antimicrobial resistance (AMR). Recent research has highlighted the unique properties of SrNPs, including their ability to promote osteogenesis, enhance bone healing, and exhibit strong antimicrobial activity against multidrug-resistant pathogens. These attributes position SrNPs as innovative therapeutic agents with the potential to address challenges such as osteoporosis, bone infections, and the growing global AMR crisis. This comprehensive review critically examines the dual functional potential of SrNPs by analyzing their synthesis methods, physicochemical properties, biological interactions, and translational applications in orthopedic and antimicrobial therapies. Specifically, the review emphasizes SrNPs' ability to enhance bone density, accelerate fracture healing, and reduce the economic burden associated with prolonged treatment and rehabilitation for bone-related diseases. Furthermore, their novel application as antimicrobial agents is explored, highlighting their ability to target bacterial metabolic pathways and combat the rise of antibiotic resistance. The review focuses on the synthesis methods used for SrNPs, particularly co-precipitation, hyd

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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