Facial Adipostructuring With Biochemical Modulation in Chronic Peripheral Facial Paralysis: A Case Report.

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Chronic peripheral facial paralysis (CPFP) implies a prolonged course without recovery of neuromuscular activity of facial expression and the biological impossibility of restoring spontaneous function. Facial paralyses, most commonly idiopathic in origin, are graded using the House-Brackmann (HB) scale, where grade I represents normal function and grades II through VI indicate progressively greater functional compromise. Furthermore, CPFP lacks satisfactory therapeutic options, and conventional strategies, botulinum toxin and surgical reanimation, neither address the collapse of facial structural support nor the dysfunction of dermal white adipose tissue (dWAT) that accompanies chronic denervation. This report presents a treatment strategy for patients with CPFP consisting of Facial Adipostructuring (AEF), a biomechanical reorganization of fat compartments via cannula-based mechanotransduction without tissue extraction, combined with biochemical modulation using dimethylaminoethanol (DMAE), organic silicon, and acetyl hexapeptide-38. The patient progressed from HB grade IV to grade I over three biweekly sessions, with improvement sustained at nine-month follow-up without additional interventions. The changes observed were consistent with improvements on the HB functional scale and were documented through standardized clinical photography. This treatment represents a minimally i

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

Browse all related research

Filter the research library by this study's title keywords, author, or publication year.