Fat-derived neural stem cells promote nerve regeneration following peripheral nerve injury.
Ott LC., Kashiwagi A., Han CY., Leavitt AR., Rahman AA., Hwang CD.
Animal Study, published in Stem Cell Res Ther (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Stem Cell Res Ther (2025)
- Country
- England
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 41430311
- PMCID
- PMC12723924
- DOI
- 10.1186/s13287-025-04800-w
- Citations
- 1
Abstract (original English)
Background Peripheral nerve injuries are associated with significant morbidity, particularly when primary surgical repair is delayed or impossible due to extensive nerve gaps. While advances in biomedical engineering have led to commercially available nerve guidance conduits tailored for such injuries, rates of sensory and motor recovery remain suboptimal following neurotmesis with gap defects beyond 3 cm. Cell therapy represents a promising treatment strategy to heal the injured peripheral nervous system, thought to promote tissue regeneration and enhance endogenous mechanisms of nerve repair to restore functionality. In this study, we explore the potential utility and efficacy of subcutaneous adipose tissue-derived neural stem cells in a nerve transection injury model. Methods Plp1-EGFP mice, which express GFP in Schwann cells, underwent surgical excision of a 5 mm segment of the left sciatic nerve. Nerves were then immediately repaired using silicone nerve guidance conduits with a residual 5 mm defect between nerve stumps. Conduits were loaded with cell culture media alone or with subcutaneous adipose tissue-derived neural stem cells harvested from Wnt1-tdTomato neural crest reporter mice, the latter enabling cell tracing post-transplantation. Results Subcutaneous adipose tissue-derived neural stem cells persisted through postoperative day 56 and contributed structurally to
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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