Fibrin Scaffold With Concentrated Growth Factor and Stromal Vascular Fraction: A Novel Approach for Repairing Chronic Rotator Cuff Tears in a Rabbit Model.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Rotator cuff tears (RCTs) represent a significant challenge in orthopaedic care, particularly in chronic cases where tendon healing is suboptimal. Novel biological therapies such as concentrated growth factor (CGF) and stromal vascular fraction (SVF) offer promising solutions for enhanced tendon repair. This study hypothesized that a fibrin scaffold enriched with CGF and SVF would improve tendon healing by reducing fatty degeneration, increasing vascularization, and enhancing biomechanical properties in a chronic RCT rabbit model. Controlled laboratory study. A chronic RCT model was developed in the subscapularis tendon of 28 male New Zealand rabbits. In the first phase (week 0), the chronic injury model was created surgically. At week 6, in addition to the transosseous repair technique, biological materials were applied into the bone tunnel in each group as follows: hydrogel (group 1), fibrin gel with CGF (group 2), CGF+SVF-enriched fibrin scaffold (group 3), and no repair (group 4). At week 12, animals were euthanized, and samples were collected for macroscopic, histological, immunohistochemical, and biomechanical analysis. Group 3 demonstrated a superior result. Fatty degeneration was significantly lower in group 3 compared with group 1 ( P = .045). Vascularization and cellularity scores were highest in group 3 (3.7 ± 0.5 and 3.6 ± 0.5, respectively), significantly greater t

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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