Fibroblast Growth Factors: Roles and Emerging Therapeutic Applications
Ternier G., Shahzad K., Edirisinghe O., Okoto P., Alraawi Z., Sonnaila S.
Narrative Review, published in Curr Drug Targets (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Curr Drug Targets (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 40051360
- PMCID
- PMC13011824
- DOI
- 10.2174/0113894501351461250301072444
- Citations
- 7
Abstract (original English)
Several fibroblast growth factors are expressed in the developmental stage, while others are present in adults. They are vital in maintaining cellular homeostasis and signaling important cellular functions, such as regeneration and growth. Over the years, a spike of interest has been observed in clinical applications of the different members of this family, especially for their implications in glucose and lipid homeostasis, cancer, and regeneration. Yet, the extent of this vast family's roles in different cellular activities and their mechanism of action remain unclear. Furthermore, they are structurally unstable molecules, making clinical applications more difficult. This work reviews the mechanism of action of FGFs and offers valuable insights into their therapeutic potential.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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