FUNCTIONAL STATE OF MULTIPOTENT MESENCHYMAL STROMAL CELLS DURING MODELING THE EFFECTS OF MICROGRAVITY.
Ratushnyy AY., Buravkova LB.
Laboratory Study, published in Aviakosm Ekolog Med (2016) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- Aviakosm Ekolog Med (2016)
- Country
- Russia (Federation)
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 29553591
- DOI
- 10.21687/0233-528x-2016-50-5-24-29
Abstract (original English)
Multipotent mesenchymal stromal cells (MMSCs) are essential for regeneration and tissue homeostasis. The investigation was focused on the functional state of MMSCs isolated from human adipose tissue and exposed to simulated microgravity in vitro by RPM (random position machine). The results point to an increase of proliferative potential, decrease of the lisosomal compartment activity, and reductions in cell size and granularity. Evaluation of the paracrine activity in relatively static control revealed increased IL-8 production and decreased IL-6 production. *Our .data supplement previous findings and allow conclude about universality of the mesenchymal cell reaction to simulated microgravity. The investigation did not detect signs of cell stress in this environment.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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