Gegen Huazhuo Tang (GHT) inhibits 7-KDCA and increases TGR5 to promote white fat browning.
Ni X., Cheng S., Jin X., Sun Y., Yang Z., Hu MG.
Randomized Controlled Trial, published in J Ethnopharmacol (2025) — summary generated from the PubMed abstract.
Several human studies show positive signals, while research methods and sample sizes continue to develop.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Randomized Controlled Trial
- Journal
- J Ethnopharmacol (2025)
- Country
- Ireland
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 40633859
- DOI
- 10.1016/j.jep.2025.120266
Abstract (original English)
Ethnopharmacological relevance Gegen Huazhuo Tang (GHT), an empirical clinical prescription for treating hyperlipidemia in China, is composed of five herbs with both medicine and food uses and one functional food derived from traditional medicine, all of which exhibit hypolipidemic and anti-obesity effects. However, ingredients and pharmacological mechanism of GHT remains unexplored. Aim of the study We investigated the role of GHT on high-fat diet (HFD)-induced obesity and its molecular regulation on adipose thermogenesis. Methods The ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q/TOF-MS) was used to identify components of GHT and metabolites in GHT-containing serum (GHTS) from GHT-treated rats. In vivo, six-week-old male C57BL/6J mice were randomly assigned to control (distilled water) and GHT (13 g/kg/day via gavage) groups fed either a normal chow diet (NCD) or HFD for 12 weeks. In vitro, adipocytes differentiated from inguinal white adipose tissue (iWAT)-isolated stromal vascular fraction (SVF) cells and 3T3-L1 preadipocytes were used to evaluate the effect of GHTS metabolites on thermogenesis. Results Thirteen chemical components were identified in GHT and eleven differential metabolites were confirmed in GHTS. GHT prevented obesity through increasing white fat browning via the parallel recruitment of UCP1-dependen
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
Evidence level
Several human studies show positive signals, while research methods and sample sizes continue to develop.
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