SVF
Level C· Early Human ResearchCohort Study

Genetic regulation of exosome biogenesis pathway in human adipose and muscle tissue and association with obesity and insulin resistance.

Das SK., Deep G., Comeau ME., Langefeld CD.

Cohort Study on Type 2 Diabetes, published in Int J Obes (Lond) (2026) — summary generated from the PubMed abstract.

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Cohort Study
Journal
Int J Obes (Lond) (2026)
Country
England
Reported sample size
—
PMID
41109913
DOI
10.1038/s41366-025-01933-z

Abstract (original English)

Animal studies provide evidence of a link between exosome profile, obesity and insulin resistance (IR). Although it is known that exosomes mediate cell-cell communication via their macromolecular cargo, the genetic factors regulating exosomes in humans are largely unknown. Leveraging genome-wide expression and genotype data from the African American Genetics of expression and Metabolism (AAGMEx) cohort, we focused on 262 genes in "Exosome pathway", curated by us, to examine the relationship of the expression of these genes with IR and obesity and tested the role of single nucleotide polymorphisms (SNPs) in determining the variability in the expression of these genes in adipose and muscle tissue. Publicly available gene expression data on European ancestry individuals, genome-wide association studies (GWAS), and bioinformatic approaches were used to validate the role of obesity-associated genetic variants in regulating exosome pathway genes. Transcript levels of 96 and 15 exosome pathway genes were associated with gluco-metabolic traits (BMI and insulin sensitivity) in adipose and muscle tissue, respectively. Data also suggest transancestral replication of association. The cis-expression quantitative trait (cis-eQTL) analysis of exosome pathway genes identified 45 and 65 cis-eGenes in adipose and muscle tissue, respectively. Expression of a subset of 26 cis-eGenes in adipose was

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.

Evidence level

Early human evidence such as case series or small samples, often without a control group.

How we grade evidence
HumansInsulin ResistanceObesityExosomesAdipose TissueGenome-Wide Association StudyPolymorphism, Single NucleotideMaleFemaleMuscle, Skeletal
HipType 2 Diabetes
View on PubMedDOI

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