Graphene-Based Polymeric Microneedles for Biomedical Applications: A Comprehensive Review
Moradi S., Nargesi Azam F., Abdollahi H., Rajabifar N., Rostami A., Guzman P.
Narrative Review, published in ACS Appl Bio Mater (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- ACS Appl Bio Mater (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 39927634
- PMCID
- PMC11921037
- DOI
- 10.1021/acsabm.4c01884
- Citations
- 7
Abstract (original English)
Transdermal drug delivery presents a promising noninvasive approach, bypassing first-pass metabolism and gastrointestinal degradation. However, the stratum corneum (SC) barrier limits drug absorption, necessitating the development of effective delivery systems. Microneedles, particularly polymer-based ones, offer a solution by penetrating the SC while avoiding critical nerves and capillaries. These microneedles are biodegradable, nontoxic, and easily manufacturable, making them a highly attractive platform for transdermal drug delivery. However, their clinical application remains limited due to suboptimal therapeutic efficacy and slow drug release rates. Recent advancements have introduced the incorporation of nanodrugs, such as nanoparticles and encapsulated drugs, into microneedles to enhance drug delivery efficiency. Among the materials explored, graphene and its derivatives, including graphene oxide (GO) and reduced graphene oxide (rGO), have garnered significant attention. Their exceptional mechanical strength, electrical conductivity, and antibacterial properties not only improve the mechanical performance of microneedles but also enhance drug release rates and biocompatibility. This review synthesizes the current state of microneedle technologies, focusing on the materials, fabrication techniques, and performance challenges. It particularly examines the potential of grap
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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