Graviola Extract versus Adipose-Derived Mesenchymal Stem Cells as Therapeutics in Repairing Liver Damage Caused by 2‑Amino-3-Methylimidazo[4, 5‑f]quinoline.
Hamada Abd El-Hafeez Thabet D., Atia MM., Abdel-Tawab HS., Alghriany AAI.
Laboratory Study, published in ACS Omega (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- ACS Omega (2025)
- Country
- United States
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 41280785
- PMCID
- PMC12631689
- DOI
- 10.1021/acsomega.5c03088
Abstract (original English)
The mutagenic and carcinogenic heterocyclic amine, 2-amino-3-methylimidazo-[4,5-f]-quinoline (IQ), is produced while cooking protein-rich foods. Mesenchymal stem cells (MSCs) (as cell-based therapy) and Annona muricata (graviola) (as a natural product) both possess preventive capacities against free radical toxicity in various tissues. This study aims to compare the therapeutic properties and effects of AD-MSCs and graviola on IQ-induced liver toxicity and DNA damage in rats. Sixty adult male rats were divided into four groups: normal unexposed control, IQ, IQ + graviola, and IQ + AD-MSCs. After 6 weeks, the rats were sacrificed, and liver tissues were examined for histopathological changes using hematoxylin-eosin staining. p53 protein expression was evaluated by immunohistochemistry, and DNA damage was measured by using the comet test. Our findings indicated that AD-MSC therapy led to the most significant improvement in DNA damage, apoptosis, and p53, LPO, AST, and ALT levels caused by IQ toxicity. Additionally, AD-MSCs reduced severe histological alterations (damage and fibrosis) in liver cells induced by IQ. However, the effectiveness of graviola treatment is limited, severely restricting its use for chronic liver toxicity. In conclusion, the initial stage of IQ-induced liver toxicity is caused by oxidative stress-induced DNA damage. Compared with graviola, AD-MSCs exhibit m
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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