Groupe pour L’Avancement de la Microchirurgie Canada (GAM) : Abstracts presented at the 31st Annual Meeting / 31e Reunion annuele June 16, 2010

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

PURPOSE: The objective was to compare the functional, psychological and disease-specific quality of life (QOL) outcomes in oral cancer patients following conservative vs. surgical treatment with resection/microvascular reconstruction. METHODS: Oral cancer patients at the Princess Margaret Hospital between January 1999–2009 provided data. Two ORN treatment groups: ORN surgical group 1 – resection/microvascular mandibular reconstruction and ORN conservative group 3 – ORN with conservative management were matched on age, sex and time since radiation with two non-ORN groups: Non-ORN surgical group 2 – surgical excision, mandibular reconstruction/radiation and non-ORN group 4 – radiation alone. One time self-report surveys included: the CES – Depression Scale (emotional distress); Affect Balance Scale (psychological well-being); and the Atkinson Life Happiness Rating Scale. Treatment-related concerns were measured using Andrykowski’s “Back to Normal” and a Fear-of-Cancer-Recurrence item and QOL using the EORTC – HN37. RESULTS: A multivariate analysis of covariance was performed comparing the 4 matched groups and controlling for empirically identified covariates. ORN surgical group 1 and non-ORN surgical group 2 reported significantly higher subjective wellbeing as compared to the non-surgically treated ORN conservative group 3 (p=0.02); due largely to depressive symptoms. ORN groups

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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