Guided bone regeneration of mandibles using chitosan scaffold seeded with characterized uncultured omental adipose-derived stromal vascular fraction: an animal study.
Mohammadi R., Amini K.
Animal Study, published in Int J Oral Maxillofac Implants (2015) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Int J Oral Maxillofac Implants (2015)
- Country
- United States
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 25615927
- DOI
- 10.11607/jomi.3542
- Citations
- 7
Abstract (original English)
Purpose The aim of this study was to assess the effect of characterized uncultured omental adipose-derived stromal vascular fraction (SVF) on bone regeneration in a circular mandibular bone defect. A chitosan scaffold was used to maintain the cells in situ. Materials and methods Seventy-five healthy male white Wistar rats were randomized into three experimental groups. In the control group, a surgical bone defect was created in the body of the mandible. In the scaffold group, a chitosan scaffold was placed into the defect. In the scaffold/SVF group, a scaffold was implanted and seeded with 10-μL SVF aliquots (2.19 ± 0.43 x 10(7) cells). Results Microscopic and histomorphometric analyses showed improved and earlier regeneration of bone defects in the scaffold/SVF group compared to the scaffold-only group. Conclusion In this animal model, the use of a chitosan scaffold with SVF aliquots resulted in significantly earlier regeneration of bone than the use of the scaffold alone.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
How we grade evidenceBrowse all related research
Filter the research library by this study's title keywords, author, or publication year.