Hierarchical therapeutic potential in the mesenchymal stem cell landscape.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Mesenchymal stem cells (MSCs) are heterogeneous and versatile cells comprising distinct subpopulations with varying regenerative potential. MSCs have been widely explored in clinical research owing to their regenerative, tissue trophic, immune modulatory, and anti-inflammatory properties. Tissue-sourced autologous and allogeneic MSCs including those isolated from bone marrow, adipose tissue, and umbilical cord have been applied to clinical studies of a breadth of indications, providing ample evidence supporting the safety of MSC-based therapies. In some instances, clinical studies of MSCs have yielded variability in cell quality, potency, and therapeutic impact. Significantly, the Food and Drug Administration’s approval of the first MSC therapy, the allogeneic bone marrow MSC product Remestemcel-L-rknd (Ryoncil®), has fueled optimism for the clinical prospects of other investigational MSC products. The functional heterogeneity of MSCs has been demonstrated by studies of MSC subpopulations, often selected by surface marker expression or functional characteristics, that vary in clonogenicity, immunomodulatory potency, trophic factor production, and differentiation potential. While MSCs possess the ability to differentiate into mesodermal lineage cells, the potential for transdifferentiation of MSCs has been a matter of extensive scientific debate. There has been a strong impetus

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

Browse all related research

Filter the research library by this study's title keywords, author, or publication year.