High-fat diets promote hematopoietic stem cell expansion and exercise reduces myeloid skewing during maintenance hematopoiesis.
Vanhie JJ., Kim W., Goode C., Collao N., Tate A., De Lisio M.
Animal Study with a reported sample of 40, published in J Appl Physiol (1985) (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- J Appl Physiol (1985) (2025)
- Country
- United States
- Reported sample size
- 40
- Source database
- PubMed
- PMID
- 40298185
- DOI
- 10.1152/japplphysiol.00899.2024
Abstract (original English)
High-fat diets (HFD) and exercise (EX) exert differential impacts on hematopoietic stem and progenitor cell (HSPC) differentiation during stress hematopoiesis, in part, through alterations in the HSPC niche. However, how HFDs and EX alter HSPC differentiation during maintenance conditions remains unknown. Therefore, we examined HSPC and niche cell concentrations during maintenance hematopoiesis following a HFD and EX training intervention. Male CBA mice ( n = 40) underwent 8 wk of HFD or control (CON) diet consumption with the latter 4 wk involving sedentary (SED) or EX training interventions. Bone marrow cells were quantified by flow cytometry, and marrow-derived HSPCs were magnetically isolated for a colony-forming unit assay. HFD mice had higher body weight, body fat percentage, and lean body mass compared with CON mice without any effect of exercise. HFD promoted HSPC and myeloid progenitor cell expansion without impacting lymphoid progenitor cells. HSPCs derived from HFD mice displayed enhanced myeloid colony formation, which was inhibited by EX. EX reduced mesenchymal stromal cell concentrations. Together, these results suggest that during maintenance hematopoiesis, EX inhibits myeloid and mesenchymal stromal cell expansion, whereas HFD opposes these effects, which is similar to their effects during stress hematopoiesis. NEW & NOTEWORTHY We are the first to show that exer
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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