High strength and low friction of a PAA-alginate-silica hydrogel as potential material for artificial soft tissues.
Lin HR., Ling MH., Lin YJ.
Laboratory Study, published in J Biomater Sci Polym Ed (2009) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- J Biomater Sci Polym Ed (2009)
- Country
- England
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 19323881
- DOI
- 10.1163/156856209X426448
- Citations
- 17
Abstract (original English)
In this study, a series of poly(acrylic) acid (PAA)-based hydrogels was prepared by UV polymerization. Hydrogels with an interpenetrating network structure were formed by combining PAA and alginate (Alg) solutions. The incorporation of nano-silica into these gel solutions significantly increased their compressive strength and fracture toughness but lowered their cross-linking density and friction coefficient. The prepared hydrogels were considerably hydrophilic for water content greater than 98%, which is in accordance with the nature of soft tissues such as cartilage. The preliminary cell culture of adipose stem cells (ADSCs) on PAA-Alg-Si hydrogels results in good biological safety. These features suggest that the PAA-Alg-Si hydrogels prepared in this study can be used as artificial soft tissues.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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