Hilnc- mediated UCP1 translation repression contributes to thermogenesis and energy expenditure.
Jiang M., Li Y., Jiang Y., Wang R., Peng J., Wang Y.
Animal Study, published in Theranostics (2026) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Theranostics (2026)
- Country
- Australia
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 41608567
- PMCID
- PMC12846010
- DOI
- 10.7150/thno.122688
Abstract (original English)
Background : Beige adipocytes play a critical role in thermoregulation by upregulating uncoupling protein 1 (UCP1) upon stimulation. While the transcriptional regulation of UCP1 in adipose tissue has been extensively investigated, the mechanisms governing its translational control remain largely elusive. Methods : A cold exposure protocol was employed to induce beige adipocyte biogenesis in mouse subcutaneous fat. The overall metabolic rate of mice was monitored by metabolic cage. Primary adipocyte precursors were isolated from the stromal vascular fraction (SVF) of inguinal white adipose tissue (iWAT) and differentiated into beige adipocytes using a standard adipogenic induction cocktail. Transmission electron microscopy (TEM) was utilized to examine mitochondrial morphology. Functional rescue experiments were performed via adenovirus-mediated gene overexpression. Potential binding partners were screened by LC-MS/MS, while RNA immunoprecipitation (RIP) and RNase protection assay (RPA) were applied to evaluate RNA-protein and RNA-RNA interactions, respectively. Additional mechanistic insights were obtained through qPCR, Western blotting, Immunohistochemistry and bioinformatics analyses. Results : In this study, we discovered that Hilnc , a long non-coding RNA (lncRNA), functions in beige adipocytes by suppressing UCP1 translation. Adipocyte-specific Hilnc -deficient mice displa
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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