Histochemical and ultrastructural criteria for early differentiation of human subcutaneous adipocytes.
Atanassova P.
Laboratory Study, published in Folia Med (Plovdiv) (1998) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- Folia Med (Plovdiv) (1998)
- Country
- Bulgaria
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 10205988
Abstract (original English)
The histochemical, enzyme-histochemical and ultrastructural characteristics of the adipocyte precursors in human embryos at 6-12 weeks of gestation were studied. Some consequent stages in the histogenesis and differentiation of the fat cells were maintained according to: 1/number and size of the lipid droplets; 2/position of the nucleus. The cells become rounder, accumulate lipid inclusions, acquire eccentric nucleus, gradually gather in clusters. No typical unilocular adipocytes were seen at this stage of fetal development. The enzyme-histochemistry disclosed that the reactions for glucose-6P-dehydrogenase, NADH2 diaphorase and especially lipoprotein lipase were highly expressed. Ultrastructurally the adipocyte precursors were with a great amount of organelles/mitochondria of typical sight, well developed rough and smooth endoplasmatic reticulum/, lipid droplets and glycogen which express their high functional activity. This study could provide criteria for understanding the processes of lipidogenesis and differentiation.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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