Hormesis: induction by <i>Aloe vera</i> extracts and individual constituents

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Aloe vera has an extensive history in traditional folk medicine. There is a robust scientific literature on Aloe vera extracts and several prominent chemical constituents, covering chemical characterization, biological/chemoprotective effects, and mechanisms. This paper provides the first integrative assessment of Aloe vera -induced hormetic dose responses. Aloe vera extract-induced hormetic responses acted as an immunostimulant in multiple fish species, enhancing development/growth and reducing adverse effects from environmental stressors. Aloe vera extract-induced hormetic effects are prominent in dermatological studies, improving keratinocyte- and fibroblast-related wound-healing processes. Aloe vera extracts induced hormetic-based neuroprotective endpoints for epileptic seizures, pain, in Alzheimer's disease models, and for lifespan. This analysis includes the hormetic effects of specific chemical constituents of Aloe vera extracts (acemannan/aloin) on stem cells, cardiomyocytes, bone cells, and other cell types, and their mechanisms. These findings show that a complex range of Aloe vera extract mixtures/specific constituents induce hormetic dose responses. These findings also indicate that hormetic dose responses play a prominent role in mediating many biomedical and chemopreventive effects of Aloe vera extracts and their major chemical constituents. Recognition of these f

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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