Human adipocytes and CD34 + cells from the stromal vascular fraction of the same adipose tissue differ in their energy metabolic enzyme configuration.
Meyer J., Engelmann R., Kamp G., Peters K.
Laboratory Study, published in Exp Cell Res (2019) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- Exp Cell Res (2019)
- Country
- United States
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 31002814
- DOI
- 10.1016/j.yexcr.2019.04.018
- Citations
- 3
Abstract (original English)
Adipose tissue plays a role in energy storage and metabolic balance and is composed of different cell types. The metabolic activity of the tissue itself has been a matter of research for a long time, but comparative data about the energy metabolism of different cell types of human subcutaneous adipose tissue are sparse. Therefore, we compared the activity of major energy metabolic pathways of adipocytes and CD34 + cells from the stromal vascular fraction (SVF) separated from the same tissue. This CD34 + cell fraction is enriched with adipose tissue-derived mesenchymal progenitors, as they account for the largest proportion of CD34 + cells of the SVF. Adipocytes displayed significantly higher mitochondrial enzyme capacities compared to CD34 + SVF-cells, as shown by the higher activities of isocitrate dehydrogenase and ß-hydroxyacyl-CoA dehydrogenase. Inversely, the CD34 + SVF-cells showed higher capacities for cytosolic carbohydrate metabolism, represented by the activity of glycolysis and the pentose phosphate pathway. Thus, the CD34 + SVF-cells may ensure the provision of pentose phosphates and reduction equivalents for the replication of DNA during proliferation. The data indicate that these two cell fractions of the human adipose tissue vary in their metabolic configuration adapted to their physiological demands regarding proliferation and differentiation in vivo.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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