Level D· Scientific groundwork from lab and animal studiesNarrative ReviewEurope PMC

Hyaluronan in adipose tissue: Beyond dermal filler and therapeutic carrier

Zhu Y., Crewe C., Scherer PE.

Narrative Review, published in Sci Transl Med (2016) — summary generated from the PubMed abstract.

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Level D· Scientific groundwork from lab and animal studiesEvidence level of this study

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

  • Level A · Stronger Clinical Evidence
  • Level B · Emerging clinical evidence with positive signals
  • Level C · Early human research exploring benefits
  • Level D · Scientific groundwork from lab and animal studies
  • Emerging · Emerging topic under active research
Read the A–D evidence level guide

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Narrative Review
Journal
Sci Transl Med (2016)
Reported sample size
—
Source database
Europe PMC
PMID
26819194
PMCID
PMC6475916
DOI
10.1126/scitranslmed.aad6793
Citations
31

Abstract (original English)

Adipose hyaluronan is increasingly recognized as an active player in adipose tissue fibrosis and metabolic dysfunction. However, this role poses as many challenges as opportunities for therapeutic targeting of adipose tissue dysfunction during nutrient oversupply.

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.
  • • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

How we grade evidence
Adipose TissueExtracellular MatrixImmune SystemAnimalsHumansObesityFibrosisNeovascularization, PathologicCollagenHyaluronoglucosaminidase

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