Hyperbaric oxygen in combination with exosomes: a new strategy to promote tissue repair
Zhang S., Zhou J., Liu J., Li T., Liu Y., Gao Y.
Narrative Review, published in Front Bioeng Biotechnol (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Front Bioeng Biotechnol (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 40994671
- PMCID
- PMC12456919
- DOI
- 10.3389/fbioe.2025.1639060
- Citations
- 1
Abstract (original English)
Tissue repair is an essential mechanism for restoring damage caused by disease and maintaining life in organisms. Hyperbaric oxygen therapy, as a non-invasive physical treatment, has been utilized to address various tissue damage conditions. Exosomes are nanoscale vesicles released into the extracellular environment by animal cells. Their structure comprises a phospholipid bilayer membrane and includes specific functional active components, such as nucleic acids, lipids, and proteins. It can precisely modulate the behavior of target cells, restore the balance of the microenvironment, and stimulate endogenous regeneration and repair mechanisms, representing a novel tool in regenerative medicine. Evidence indicates that hyperbaric oxygen in conjunction with exosomes can markedly enhance tissue healing. Currently, there is a paucity of research about the synergistic application of the two, however they are intrinsically linked to the principles of tissue repair. Therefore, this article systematically explains the application and mechanism of hyperbaric oxygen and exosomes therapy on tissue repair, the interaction between the two, and the combined application of the two, and analyzes the safety and transformation obstacles of the combined treatment strategy, in order to provide new ideas for future combined research and clinical application.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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