Identification and characterization of adult stem cells from human orbital adipose tissue.
Korn BS., Kikkawa DO., Hicok KC.
Laboratory Study, published in Ophthalmic Plast Reconstr Surg (2009) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- Ophthalmic Plast Reconstr Surg (2009)
- Country
- United States
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 19273919
- DOI
- 10.1097/IOP.0b013e3181912292
- Citations
- 53
Abstract (original English)
Purpose To identify pluripotential stem cells from human orbital adipose depots. Methods Pluripotential adipose-derived stem cells were isolated from human orbital adipose during routine blepharoplasty surgery. Fresh adipose tissue was separated in nasal fat and central (preaponeurotic) fat. Individual adipose depots were minced, enzymatically digested, and plated on plastic culture dishes. Adherent populations of cells were expanded in culture, characterized by flow cytometry, and assayed for the potential to differentiate in different cell lineages. Results Orbital adipose-derived cells from the nasal and central adipose depots showed the potential to differentiate into the adipocyte, smooth muscle, and neuronal/glial lineages and expressed a CD marker protein profile consistent with that observed for adipose-derived stem cells from other adipose depots. Conclusions A population of adherent cells capable of pluripotential differentiation in vitro exists within adult human orbital adipose tissue. These cells are similar to those described in other adipose depots and will help facilitate understanding of orbital diseases and may provide a novel tissue source for the development of ocular regenerative medicine therapies.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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