Identification of SDC4 as a potential target for obesity via integrated analysis of the lncRNA-miRNA-mRNA network in visceral adipose tissue
Shao Y., Ju F., Qian J., Tang L., Chen S.
Laboratory Study, published in Adipocyte (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- Adipocyte (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 41199597
- PMCID
- PMC12599498
- DOI
- 10.1080/21623945.2025.2583542
Abstract (original English)
Obesity is a major global health issue. This study aimed to elucidate its molecular mechanisms by analysing the expression of lncRNAs, miRNAs, and mRNAs in visceral adipose tissue. Through integrated transcriptome sequencing and bioinformatics analysis of obese and normal groups, we observed 118, 92 and 227 differentially expressed lncRNAs, miRNAs and mRNAs, respectively. Functional enrichment analysis revealed these genes were primarily involved in immune response and inflammation-related pathways. A competing endogenous RNA (ceRNA) network was constructed, identifying key interactions among five target genes, including SDC4. Validation confirmed SDC4 was significantly upregulated in obese subjects, and this expression level positively correlated with body mass index and triglyceride. These findings suggest that SDC4 offers the possibility of being a therapeutic target for obesity.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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