Immediate Autologous Granular Fat Grafting with Modified Techniques for Chronic Prosthetic Rhinoplasty Infection: A Single-Case Experience
Yang Q., Zheng H., Wang Y., Zheng X., Wu J., Zhao H.
Case Report / Series, published in Clin Cosmet Investig Dermatol (2026) — summary generated from the PubMed abstract.
Early human evidence such as case series or small samples is exploring possible benefits.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Case Report / Series
- Journal
- Clin Cosmet Investig Dermatol (2026)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 42137405
- PMCID
- PMC13170587
- DOI
- 10.2147/ccid.s603914
Abstract (original English)
Managing chronic infection after prosthetic rhinoplasty is clinically challenging. Traditional staged treatment involves prolonged waiting periods, often leading to nasal dorsum collapse, soft tissue contracture, and increased difficulty of secondary surgeries. Immediate autologous fat grafting after infected implant removal has been reported, but technical limitations such as unstandardized debridement and aggressive fat processing remain. We report a case of a 48-year-old female patient with chronic infection one year after ePTFE prosthetic rhinoplasty, unresponsive to a 2-week course of oral amoxicillin-clavulanate potassium. A single-stage procedure was performed, including complete prosthesis and capsule removal, restricted cavity debridement, and immediate transplantation of minimally processed autologous granular fat (simple gauze filtration without washing/centrifugation) into the original cavity. During one-year follow-up, no signs of infection recurrence were observed, and the nasal dorsum contour remained stable and natural without collapse or deformity. The patient reported satisfaction with the aesthetic outcome and declined further implant-based surgery. This single-case experience suggests that single-stage debridement combined with immediate autologous granular fat grafting may be feasible for carefully selected patients with chronic, localized, low-virulence pr
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • Without an adequate control group, treatment effects cannot be separated from other factors.
Evidence level
Early human evidence such as case series or small samples is exploring possible benefits.
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