Immune escape of <i>Staphylococcus aureus</i> mediated by osteocyte lacuna-canalicular network leads to persistent and uncured bone infection
Rong Z., Chen X., Qin L., Wang X., Luo F., Zou Q.
Narrative Review, published in Front Cell Infect Microbiol (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Front Cell Infect Microbiol (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 40529302
- PMCID
- PMC12171435
- DOI
- 10.3389/fcimb.2025.1592086
- Citations
- 1
Abstract (original English)
Bone infections, specifically chronic osteomyelitis, are characterized by recurrent episodes. They are considered intractable clinical diseases as they require protracted and difficult-to-cure courses. Staphylococcus aureus ( S. aureus ) is the most common pathogen responsible for bone infections and has high destruction rates. Previous literature has indicated that during S. aureus osteomyelitis, immune evasion mainly involves three mechanisms: biofilm formation, intracellular infection, and abscess formation. However, recently, it was observed that S. aureus can enter and persist for a long time in the Osteocyte lacuno-canalicular network (OLCN), a bone microstructure. Furthermore, it has been found to successfully evade the host's immune system via natural physical barriers, chemical properties, and bone microstructure's immune escape mechanisms. Therefore, S. aureus bone infections are more difficult to cure than soft-tissue infections. Currently, there are only a few studies on OLCN invasion by S. aureus , and the clinical evidence is not sufficient. Therefore, this review aimed to combine relevant published literature on the OLCN-mediated immune escape of S. aureus to elaborate on the pathological mechanisms associated with protracted and difficult-to-cure bone infections. The findings will provide a scientific basis and theoretical foundation for future comprehensive ana
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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