The impact of acemannan, an extracted product from Aloe vera , on proliferation of dental pulp stem cells and healing of mandibular defects in rabbits
Mehrabani D., Sholehvar F., Yaghmaei P., Zare S., Razeghian-Jahromi I., Jalli R.
Animal Study, published in Am J Stem Cells (2024) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Am J Stem Cells (2024)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 38765804
- PMCID
- PMC11101985
- DOI
- 10.62347/uafc3719
- Citations
- 3
Abstract (original English)
Objectives Dental pulp stem cells (DPSCs) were shown to play an important role in regenerative medicine including reconstruction of various bone lesions. This study determined the impact of acemannan, an extracted product from Aloe vera , on in vitro proliferation of DPSCs and in vivo healing of mandibular defects in rabbits. Methods DPSCs were isolated and characterized. The growth kinetics of cells exposed to acemannan (8 mg/mL) and Hank's balanced salt solution (HBSS) were compared in vitro . Fifteen male rabbits were divided into 3 groups. Five animals were left as control group without any therapeutic intervention. Five rabbits were considered as experimental group 1 and received 20 µL of a cell suspension containing 10 6 DPSCs in the bone defect. Another 5 rabbits were regarded as experimental group 2 and were injected in the bone defect with 20 µL of a cell suspension containing 10 6 DPSCs treated with acemannan for 24 h. After 60 days, the animals were assessed by radiography and histologically. Results The mesenchymal properties of DPSCs were confirmed. Population doubling time (PDT) of DPSCs treated with acemannan (29.8 h) was significantly shorter than cells were just exposed to HBSS (45.9 h). DPSCs together with acemannan could significantly accelerate the healing process and osteogenesis in mandibular defects. Conclusions As DPSCS showed an increased proliferation
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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