Impact of climate change on adipose-derived stem cells: A molecular and histological study.
Zarandi SM., Yarahmadi R., Nasiri R., Bayat M., Nasiri H., Amini A.
Laboratory Study, published in J Clim Chang Health (2024) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- J Clim Chang Health (2024)
- Country
- France
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 41646244
- PMCID
- PMC12851270
- DOI
- 10.1016/j.joclim.2024.100367
Abstract (original English)
Background Climate change, particularly temperature and humidity fluctuations, can affect biological systems. This study specifically investigates the impact of these two key aspects of climate change on adipose-derived stem cells (ADSCs) as a pilot study and starting point for further examinations into the biological effects of climate change-associated conditions. Methods One-month-old male rats were kept for 4 months (equal to a 10-year climatic period) in 4 groups and exposed to conditions based on climatic data from Tehran's synoptic stations. Rats in the control group were exposed to conditions based on climatic data from 1991, and groups 2-4 were exposed to conditions based on climatic data from 1991 to 2000, 2001-2010, and 2011-2020, respectively. Monthly temperature, humidity, and day/night cycle averages were selected for animal exposure. After exposure, fat-derived stem cells were taken from each subject and assays assessing reactive oxygen species (ROS), cell viability and proliferation, and apoptosis were performed. Results From 1991 to 2020, Tehran experienced an average temperature increase of 1.5 °C and a 15 % decrease in average humidity, conditions which when replicated in rodent models were associated with increased rates of ROS and caspase-3 expression, a reduction in Ki-67 antigen expression and in the duration of the life of cells, and an increase in the r
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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