Improved Skin Quality with a Novel Topical Body Serum: Distal Thighs and Back of Hands

Several human studies show positive signals, while research methods and sample sizes continue to develop.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background Intrinsic and extrinsic factors contribute to the loss of dermal extracellular matrix (ECM), which can result in a decline of skin quality and clinical signs of aging skin. Objective This randomized, double-blinded, split-body, vehicle-controlled, 12-week study evaluated the efficacy of a skin body firming serum (BFS) that targets ECM renewal to improve skin quality on the distal thighs and back of hands. Methods Adults with mild-to-moderate skin crepiness applied either BFS or vehicle twice daily to their assigned treatment side. Clinical investigator assessments, digital imaging, and participant self-assessments were performed. Skin biopsies were taken from a limited number of participants for histologic analysis. Results Participants were divided into 2 groups: treatment on the distal thighs (N = 11) and treatment on the back of hands (N = 12). Significant improvements in distal thigh firmness, texture, crepiness, and fine lines/wrinkles were observed from BFS treatment at weeks 4 and 12 over vehicle treatment and baseline. Firmness and texture on the back of hands significantly improved at weeks 8 and 12 of BFS treatment relative to baseline, with crepiness significantly improving at weeks 2 and 12. Significant improvements were seen in body skin texture (distal thighs), firmness (back of hands), and crepiness (back of hands) at week 12, and fine lines/wrinkles (

Evidence level

Several human studies show positive signals, while research methods and sample sizes continue to develop.

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