Incorporation of tripolyphosphate nanoparticles into fibrous poly(lactide-co-glycolide) scaffolds for tissue engineering.
Xie S., Zhu Q., Wang B., Gu H., Liu W., Cui L.
Animal Study, published in Biomaterials (2010) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Biomaterials (2010)
- Country
- Netherlands
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 20347132
- DOI
- 10.1016/j.biomaterials.2010.03.004
- Citations
- 17
Abstract (original English)
Poly(lactide-co-glycolide) (PLGA) has been widely used for scaffolding materials in tissue engineering. It degrades mainly via hydrolysis of the ester bonds into lactic acid and glycolic acid leading to the decrease in pH of the surrounding microenvironment. The current study was designed to quickly neutralize the acidic degradation products of PLGA fibrous scaffolds by incorporating tripolyphosphate (TPP) nanoparticles into PLGA fibers. A homogeneous mixture of PLGA and TPP was first obtained by water-in-oil emulsion-dispersion followed by freeze-drying. The dried blend was melt-spun to yield fibers which were processed into scaffolds and subsequently immersed into phosphate-buffered saline (PBS) to verify the degradation properties. The pH of the saline was monitored for a duration of 80 days. The amount of TPP was optimized to obtain a PLGA based scaffolds without acidic degradation problems. Cellular compatibility of the modified and pristine scaffolds was evaluated using rabbit adipose-derived stem cells (rASCs). It was shown that TPP particles within the fibers were roughly 100nm in diameter and mainly located inside fibers instead of on the superficial layer. The acidic degradation of PT-16 and PT-64 (PT-X is termed when the monomer molar ratio of TPP to PLGA was 1:X) was significantly improved as the pH values of their respective solutions were maintained in a well neut
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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