Influence of PEEK surface modification with titanium for improving osseointegration: an in vitro study

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

This study aimed to examine the impact of PEEK surface modification with titanium to enhance osseointegration. The assessment included the bond strength of the TiO 2 surface coating, as well as an analysis of the hydrophilicity and cell adhesion properties of TiO 2 -coated PEEK. The study also explored whether aging affected TiO 2 -coated PEEK. The study used 51 disk specimens of ceramic-reinforced PEEK, prepared by wet milling. The disk surfaces were polished and divided into three groups based on surface modification or treatment. The control group (CG) included seven specimens without TiO 2 coating. The nascent group included 22 TiO 2 -surface-coated specimens, subdivided equally into the untreated nascent group (NG) and the photo-functionalized, UV-treated nascent group (NGP). The remaining specimens were aged for four weeks and similarly divided into the untreated aged group (AG) and the photo-functionalized, UV-treated aged group (AGP). In the CG, three specimens were evaluated for hydrophilicity, and the remaining four for stem cell culture. For the NG, NGP, AG, and AGP groups, three specimens were evaluated for hydrophilicity, while four specimens were assessed for cell growth and TiO 2 coating bond strength. Bond strength was evaluated using a scratch test, showing an average strength of 24.56 ± 2.28 MPa, with no significant difference between groups. Hydrophilicity wa

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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