SVF
Level A· Stronger Clinical EvidenceSystematic Review

Injectable Fillers for Atrophic Acne Scars: A Systematic Review of Mechanisms, Evidence, and Clinical Algorithms.

Tao A., Shu Y., Ding H., Tao G.

Systematic Review on Scar, published in Clin Cosmet Investig Dermatol (2026) — summary generated from the PubMed abstract.

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Systematic Review
Journal
Clin Cosmet Investig Dermatol (2026)
Country
New Zealand
Reported sample size
—
PMID
41978687
DOI
10.2147/CCID.S602580

Abstract (original English)

Acne affects 9.4% of the global population, with the highest prevalence among adolescent males (12-25 years of age). More than 95% of patients develop persistent scarring, predominantly atrophic acne scars (AAS). These scars markedly impair facial aesthetics, psychological well-being, and quality of life, and increase the risk of depression and suicidal ideation. Conventional therapies (eg, Dermabrasion, Subcision and Traditional Ablative Lasers) show limited efficacy for shallow AAS and are associated with procedural pain, delayed onset of improvement, and a need for repeated sessions. Dermal fillers provide a promising alternative by delivering immediate volumetric correction and aesthetic enhancement while also stimulating long-term collagen production with minimal invasiveness and favorable safety profiles. They therefore represent a novel therapeutic approach for AAS. This review systematically evaluates the clinical utility of dermal fillers for treating AAS and explores future diagnostic and therapeutic approaches. We searched the PubMed and Web of Science databases for studies published in the past 10 years, categorizing and evaluating the efficacy and adverse effects of different dermal fillers for treating AAS. Twenty-four studies met inclusion criteria, involving collagen-based fillers, hyaluronic acid fillers, collagen stimulator fillers, autologous fat, and decellu

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

How we grade evidence
Face & SkinScar
View on PubMedDOI

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