Injectable Fillers for Atrophic Acne Scars: A Systematic Review of Mechanisms, Evidence, and Clinical Algorithms.

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background Acne affects 9.4% of the global population, with the highest prevalence among adolescent males (12-25 years of age). More than 95% of patients develop persistent scarring, predominantly atrophic acne scars (AAS). These scars markedly impair facial aesthetics, psychological well-being, and quality of life, and increase the risk of depression and suicidal ideation. Conventional therapies (eg, Dermabrasion, Subcision and Traditional Ablative Lasers) show limited efficacy for shallow AAS and are associated with procedural pain, delayed onset of improvement, and a need for repeated sessions. Dermal fillers provide a promising alternative by delivering immediate volumetric correction and aesthetic enhancement while also stimulating long-term collagen production with minimal invasiveness and favorable safety profiles. They therefore represent a novel therapeutic approach for AAS. Aim This review systematically evaluates the clinical utility of dermal fillers for treating AAS and explores future diagnostic and therapeutic approaches. Methods We searched the PubMed and Web of Science databases for studies published in the past 10 years, categorizing and evaluating the efficacy and adverse effects of different dermal fillers for treating AAS. Results Twenty-four studies met inclusion criteria, involving collagen-based fillers, hyaluronic acid fillers, collagen stimulator fille

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

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