An injectable microsphere-reinforced system for sustained delivery of Adipo-MBV in adipose tissue engineering.
Xu M., Chen J., Sun Y., Yang H., Ji H., Xu T.
Animal Study, published in J Adv Res (2026) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- J Adv Res (2026)
- Country
- Egypt
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 41611126
- DOI
- 10.1016/j.jare.2026.01.058
Abstract (original English)
Tissue engineering has become prominence in soft tissue reconstruction. Adipogenesis and angiogenesis are important in the formation of engineering adipose tissue. Although acellular adipose matrix (AAM) possesses potential in adipogenic induction, obvious limitations remain in the realization of the authentic physiological regeneration. Matrix-bound nanovesicles (MBVs), located on the extracellular matrix (ECM) scaffold, provide cues for the adipogenesis property of AAM. The bioactive components within ECM are influenced by the isolation procedures. This study aimed to extract and identify adipose-derived MBVs (Adipo-MBVs) from adipose ECM scaffolds and clarify their effective role in engineering adipose tissue formation. Adipo-MBVs were extracted from two types of adipose ECM, including chemically decellularized matrix (i.e., AAM) and mechanically concentrated ECM (i.e., adipose collagen fragment, ACF). The influence of Adipo-MBVs on cell functions were estimated in vitro. In addition, AAM-hyaluronic acid methacrylate (HAMA) hybrid hydrogel (A/H) with polydopamine (PDA)-coated HAMA microspheres (PDA@HMs) was designed to sustainedly release Adipo-MBVs in an animal model. The results showed that Adipo-MBVs effectively recapitulated AAM effects on the construction of engineering adipose tissue. Crucially, mechanical Adipo-MBVs (M-AT-MBVs) derived from mechanically concentrated E
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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