Insight into Hypoxia Stemness Control
Di Mattia M., Mauro A., Citeroni MR., Dufrusine B., Peserico A., Russo V.
Narrative Review, published in Cells (2021) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Cells (2021)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 34440930
- PMCID
- PMC8394199
- DOI
- 10.3390/cells10082161
- Citations
- 34
Abstract (original English)
Recently, the research on stemness and multilineage differentiation mechanisms has greatly increased its value due to the potential therapeutic impact of stem cell-based approaches. Stem cells modulate their self-renewing and differentiation capacities in response to endogenous and/or extrinsic factors that can control stem cell fate. One key factor controlling stem cell phenotype is oxygen (O 2 ). Several pieces of evidence demonstrated that the complexity of reproducing O 2 physiological tensions and gradients in culture is responsible for defective stem cell behavior in vitro and after transplantation. This evidence is still worsened by considering that stem cells are conventionally incubated under non-physiological air O 2 tension (21%). Therefore, the study of mechanisms and signaling activated at lower O 2 tension, such as those existing under native microenvironments (referred to as hypoxia), represent an effective strategy to define if O 2 is essential in preserving naïve stemness potential as well as in modulating their differentiation. Starting from this premise, the goal of the present review is to report the status of the art about the link existing between hypoxia and stemness providing insight into the factors/molecules involved, to design targeted strategies that, recapitulating naïve O 2 signals, enable towards the therapeutic use of stem cell for tissue enginee
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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