Integrated lipidomics and transcriptomics reveal different lipid profiles and metabolic pathways in cultured fats from porcine subcutaneous adipocytes and fibro-adipogenic progenitors.
Gu X., Li Q., Liu S., Tan LP., Valencak TG., Shan T.
Animal Study, published in Food Chem (2026) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Food Chem (2026)
- Country
- England
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 42155267
- DOI
- 10.1016/j.foodchem.2026.149682
Abstract (original English)
Pork is a primary dietary protein source for humans, with its lipid composition being a critical determinant of meat quality and nutritional value. Existing studies have confirmed that intramuscular fat (IMF) and subcutaneous fat possess distinct lipid metabolic profiles. However, the lipid profiles of cultured fats from distinct seed cells remain uncharacterized. Here, we compared lipid composition of cultured fats produced from porcine subcutaneous pre-adipocytes (SAT) and fibro-adipogenic progenitors (FAPs) using a liquid chromatography-mass spectrometry approach. The FAPs-derived cultured fat exhibited significantly lower total lipid content but higher proportions of glycerophospholipids, whereas SAT-derived cultured fat showed higher levels of triglycerides and ceramides. Transcriptomics revealed distinct expression patterns of key genes involved in glycerolipid, glycerophospholipid, and sphingolipid metabolism, including DGAT1/2, CHKA, CHPT1, CEPT1, and CERS1, underpinning the observed lipid differences. Our findings provide insights into cell-type-specific lipid characteristics and a basis for optimizing cultured fat nutritional quality via seed cell selection.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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