Integrated multi-omics analysis of metabolome and transcriptome profiles during bovine adipocyte differentiation reveals functional divergence of FADS2 isoforms in lipid metabolism regulation
Zhang X., Li F., Peng L., Huang W., Du Y., Yang L.
Animal Study, published in BMC Genomics (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- BMC Genomics (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 40340639
- PMCID
- PMC12063249
- DOI
- 10.1186/s12864-025-11650-6
- Citations
- 3
Abstract (original English)
Background Fat metabolism plays an important role in animal health and economic benefits. However, the changes in gene expression and metabolites during fat metabolism have not been systematically studied in bovine. Results This study integrates transcriptomic and metabolomic strategies to delineate the metabolic and gene expression profiles during the adipogenesis of bovine preadipocytes in four different stages. Totally, we identified 328 differentially expressed metabolites (DEMs) and 5257 differentially expressed genes (DEGs) during adipogenesis. Functional enrichment of both DEMs and DEGs highlighted the important roles of fatty acid metabolic pathways. By integrating transcriptomic and metabolomic data, we identified key genes potentially regulating fatty acid metabolism, including FADS2, ACOT7 and ACOT2. We further applied comparison for the functional differences between two FADS2 isoforms (FADS2-T0 and FADS2-T2). The results proved that the lipid metabolism regulated by FADS2-2 has changed due to the loss of 46 amino acids with a transmembrane domain, which finally altering its promoting effect on bovine fat deposition. Conclusions In summary, our research provides important resources and key candidate genes for a systematic understanding of the changes in gene expression and lipid metabolism during the process of fat deposition.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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