Integration of Multiomics Data Reveals Selection Characteristics of <i>ITGB1</i> That Are Associated with Size Differentiation in Pigs
Wu G., Yu M., Liu T., Zhang D., Chang Y., Liu Z.
Animal Study, published in Int J Mol Sci (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Int J Mol Sci (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 40004035
- PMCID
- PMC11855449
- DOI
- 10.3390/ijms26041569
- Citations
- 3
Abstract (original English)
Min pigs, a prominent local breed from Northeast China, have diverged into two distinct breeds, Ermin (EM) pigs and Hebao (HB) pigs, through prolonged natural and artificial selection. Although these two breeds exhibit distinct differences in body size, the genetic mechanisms underlying this variation remain poorly understood. In this study, we performed whole-genome resequencing and transcriptome analysis on EM and HB pigs to elucidate the genetic basis of body size variation in Min pigs through genome-wide selection signal analysis and the identification of differentially expressed genes (DEGs). The analysis of genetic diversity and population genetic structure across 14 pig breeds revealed that, compared with other breeds, Min pigs present relatively high genetic diversity and a unique genetic structure. Notably, EM pigs exhibited significant genetic differentiation from HB pigs. Integrated analysis of whole-genome resequencing and transcriptome data revealed candidate genes associated with body size variation in Min pigs, including ENPP1 , ENPP3 , SPP1 , CLU , ITGA11 , ITGB1 , IQGAP2 , BMP7 , and F2RL2 . These genes are enriched primarily in pathways related to ECM-receptor interactions; pantothenate and CoA biosynthesis; starch and sucrose metabolism; nicotinate and nicotinamide metabolism; pyrimidine metabolism; nucleotide metabolism; cellular responses to lipids; biomine
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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