Intelligent polymeric hydrogen sulfide delivery systems for therapeutic applications
Rong F., Wang T., Zhou Q., Peng H., Yang J., Fan Q.
Narrative Review, published in Bioact Mater (2023) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Bioact Mater (2023)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 35510171
- PMCID
- PMC9034248
- DOI
- 10.1016/j.bioactmat.2022.03.043
- Citations
- 89
Abstract (original English)
Hydrogen sulfide (H 2 S) plays an important role in regulating various pathological processes such as protecting mammalian cell from harmful injuries, promoting tissue regeneration, and regulating the process of various diseases caused by physiological disorders. Studies have revealed that the physiological effects of H 2 S are highly associated with its concentrations. At relatively low concentration, H 2 S shows beneficial functions. However, long-time and high-dose donation of H 2 S would inhibit regular biological process, resulting in cell dysfunction and apoptosis. To regulate the dosage of H 2 S delivery for precision medicine, H 2 S delivery systems with intelligent characteristics were developed and a variety of biocompatibility polymers have been utilized to establish intelligent polymeric H 2 S delivery systems, with the abilities to specifically target the lesions, smartly respond to pathological microenvironments, as well as real-timely monitor H 2 S delivery and lesion conditions by incorporating imaging-capable moieties. In this review, we focus on the design, preparation, and therapeutic applications of intelligent polymeric H 2 S delivery systems in cardiovascular therapy, inflammatory therapy, tissue regenerative therapy, cancer therapy and bacteria-associated therapy. Strategies for precise H 2 S therapies especially imaging-guided H 2 S theranostics are high
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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