Investigating the Influence of Tranexamic Acid on Adipocyte Differentiation in an In Vitro Model.
Ellis G., DeSouza T., Challagonda J., Furrukh AJ., Joo A., Palmieri S.
Laboratory Study, published in Ann Plast Surg (2026) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- Ann Plast Surg (2026)
- Country
- United States
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 41885773
- DOI
- 10.1097/SAP.0000000000004702
Abstract (original English)
Background Tranexamic acid (TXA) is widely used in plastic surgery to reduce perioperative blood loss, hematoma formation, and postoperative ecchymosis. Its incorporation into tumescent solution for liposuction and fat grafting has increased; however, the effects of TXA on adipose tissue biology and progenitor cell function remain incompletely understood. Methods Human subcutaneous adipose tissue explants were cultured in a 3-dimensional system with vehicle control (0), 5, 10, 100, and 1000μg/mL TXA. Capillary sprouting was assessed from days 4 to 11. After 14 days, human adipose capillary-associated progenitor cells (HACAPs) were isolated from explants and expanded in 2-dimensional culture under identical TXA conditions. An independent HACAP line derived from panniculectomy tissue was evaluated in parallel. Cell proliferation was assessed over 2 to 3 expansion cycles. Adipogenic differentiation was induced using standard differentiation media and evaluated by lipid accumulation and RT-qPCR for adipogenic markers (AdipoQ, PLIN1, FABP4). Thermogenic responsiveness was assessed after forskolin stimulation by measuring expression of UCP1, LINC473, and DIO2. Results Increasing TXA concentrations were associated with a transient attenuation of early capillary sprouting at early time points (≤4d); this effect resolved by day 5, with no sustained differences in sprouting thereafter. H
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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