Investigation of the Effect of Preconditioning with Ultrasound on Fat Graft Survival
Yılmaz A., Yılmaz BK., Karaca Ç., Karasu N.
Animal Study, published in Aesthetic Plast Surg (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Aesthetic Plast Surg (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 40111431
- PMCID
- PMC12222318
- DOI
- 10.1007/s00266-025-04771-6
Abstract (original English)
Background The use of fat grafts in plastic, reconstructive, and aesthetic surgery has been increasing. Although fat grafting has many advantages, there is limited evidence regarding its survival rates. Current studies focus on improving fat graft survival rates. This study aimed to evaluate the effect of therapeutic ultrasound (TERUS) application on fat graft survival. Methods The study involved 42 adult male Wistar Albino rats, which were randomly divided into seven groups of six rats each: Group 1 served as the control group and received only fat grafting; Group 2 received preoperative daily TERUS for one week, followed by fat grafting; Group 3 underwent preoperative daily massage for one week, followed by fat grafting; Group 4 received preoperative daily TERUS for one week, followed by fat grafting and postoperative daily TERUS for one week; Group 5 underwent preoperative daily massage for one week, followed by fat grafting and postoperative daily massage for one week; Group 6 received postoperative daily TERUS for one week; and Group 7 received postoperative daily massage for one week. After volume and weight measurements, immunohistochemical evaluation was conducted using perilipin and PECAM-1. Apoptosis was assessed using the TUNEL method. Results No statistically significant differences were observed in the macroscopic measurements. While TERUS increased the vasculariza
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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