Janus Membranes as Multifunctional Nanostructures for Bone Defect Repair: Advances, Challenges, and Clinical Translation
Liu J., Liu S., Tan R., Chang W., Chen Z., Wang Y.
Narrative Review, published in Int J Nanomedicine (2026) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Int J Nanomedicine (2026)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 41878124
- PMCID
- PMC13006338
- DOI
- 10.2147/ijn.s563011
Abstract (original English)
Bone defect repair, particularly for critically sized defects, remains a formidable clinical challenge owing to the limitations of conventional bone grafts and single-functional scaffolds. Janus membranes, with their asymmetric structure and capacity for multi-functional integration, offer an innovative "all-in-one" solution for bone tissue engineering. This review systematically outlines recent advancements in Janus membranes for bone repair, focusing on three core aspects: nanofabrication strategies for achieving asymmetric properties (eg wettability, charge, and porosity), multi-functional designs that mimic the natural periosteum for guided bone regeneration, antibacterial activity, soft-tissue integration, and haemostasis, and clinical translation potential along with future perspectives. This review summarises the progress in the use of Janus membranes as multi-functional nanostructures for bone regeneration. It systematically introduces the manufacturing techniques for Janus membranes, such as the layer-by-layer method and ion-modification approaches. Furthermore, it focuses on the dual-functional and multi-functional designs of Janus membranes and their integration with nanotechnology. In addition, we delve into the current challenges (eg complexity in manufacturing processes and limited research on material mechanical properties) and propose potential solutions, such a
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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