Level B· Emerging Clinical Evidence
Stromal Vascular Fraction-Assisted Fat Grafting: A Systematic Review and Meta-analysis of Clinical Outcomes
Jefri Z.E., Alashjaee R.H., Almarri A.K., Fadel Z.T.
Meta-analysis comparing SVF-enriched fat grafting with conventional technique, assessing graft retention and safety.
- Study type
- Meta-analysis
- Journal
- Aesthetic Plastic Surgery (2026)
- Country
- Saudi Arabia
- Sample size
- —
- Follow-up
- Varied across included studies
- PMID
- 41501426
- DOI
- 10.1007/s00266-025-05511-6
What was studied
Whether SVF reduces resorption of grafted fat compared with conventional fat grafting.
Methods
- • Searched Web of Science, PubMed, Embase, Ovid Cochrane and Google Scholar to September 2025 following PRISMA.
- • Risk of bias assessed with RoB-2, the Newcastle-Ottawa Scale and ROBINS-I.
Key findings
- • Random-effects pooling of mean differences and risk ratios with I² heterogeneity assessment.
- • Included both RCTs and observational studies, producing mixed evidence quality.
Limitations
- • Heterogeneity in SVF preparation and volumetric measurement methods.
- • Observational studies carry higher risk of bias.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • Limited follow-up cannot indicate long-term outcomes.
Clinical interpretation
The most recent synthesis for aesthetic surgery using SVF to supplement fat grafting.
Evidence level: Emerging Clinical Evidence