Knowledge mapping of exosomes in ischemic stroke: a bibliometric analysis

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background Ischemic stroke is a disease in which local ischemia and hypoxia of brain tissues are caused by obstruction of blood vessels in the brain, which in turn triggers brain tissue damage and neurological dysfunction. Recent studies have made significant progress in understanding the role of exosomes in ischemic stroke. Exosomes exhibit anti-inflammatory, immunomodulatory, anti-apoptotic, angiogenic, and neuroregenerative effects, as well as glial scar reduction and drug delivery effects in ischemic stroke. However, there is a notable gap in bibliometric analyses that focus specifically on this subject. This study systematically evaluated the current knowledge and identified emerging research trends regarding exosomes in ischemic stroke through a bibliometric analysis. Methods We retrieved research articles on the role of exosomes in ischemic stroke published between 2004 and 2023 from the Web of Science Core Collection (WoSCC) database and then conducted a bibliometric analysis using VOSviewer, CiteSpace, and the bibliometrix package in the R programming environment. Results A comprehensive analysis of 374 publications from 38 countries revealed a steady increase in research focused on exosomes in ischemic stroke. This analysis significantly emphasized the contributions of researchers from China and the United States. Key research institutions in this field include Henry

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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