Level D· Scientific groundwork from lab and animal studiesLaboratory StudyEurope PMCOpen access

Latest progress in tyrosine kinase inhibitors

Pospelova TV., Pospelov VA.

Laboratory Study, published in Oncotarget (2014) — summary generated from the PubMed abstract.

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Level D· Scientific groundwork from lab and animal studiesEvidence level of this study

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

  • Level A · Stronger Clinical Evidence
  • Level B · Emerging clinical evidence with positive signals
  • Level C · Early human research exploring benefits
  • Level D · Scientific groundwork from lab and animal studies
  • Emerging · Emerging topic under active research
Read the A–D evidence level guide

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Laboratory Study
Journal
Oncotarget (2014)
Reported sample size
—
Source database
Europe PMC
PMID
24727648
PMCID
PMC4012733
DOI
10.18632/oncotarget.1836
Citations
1

Abstract (original English)

Here we discuss the latest progress in development of some kinase inhibitors such as inhibitors of c-MET, LIM and Bcr-Abl kinases. Importantly, many oncogenic kinases signal via the mTOR pathway, suggesting a common target for drug combinations.

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.
  • • This is preclinical work; animal or laboratory results cannot be applied to humans.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

How we grade evidence
HumansNeoplasmsNF-kappa BSignal TransductionProto-Oncogene Proteins c-metProtein-Tyrosine KinasesLim KinasesTOR Serine-Threonine Kinases

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