Lessons from single cell omics: admixed American ancestry and sex confer cardiometabolic disease risk in Mexicans
Kar A., Lee SHT., Alvarez M., Rajkumar S., Das SS., Ochoa-Guzmán A.
Cohort Study with a reported sample of 49, published in Genome Med (2026) — summary generated from the PubMed abstract.
Early human evidence such as case series or small samples is exploring possible benefits.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Cohort Study
- Journal
- Genome Med (2026)
- Reported sample size
- 49
- Source database
- Europe PMC
- PMID
- 41896987
- PMCID
- PMC13151335
- DOI
- 10.1186/s13073-026-01633-x
- Citations
- 1
Abstract (original English)
BACKGROUND: Subcutaneous adipose tissue (SAT), the key human fat depot for cardiometabolic health, exhibits high cellular heterogeneity. However, the contributions of contexts and cardiometabolic diseases (CMDs) to this heterogeneity are poorly understood, especially in admixed populations. Despite the substantially increased risk of obesity and obesity-related CMDs in Mexicans, cell-type-level mechanisms behind their elevated CMD risk have remained elusive. METHODS: To investigate how cell-type and subcell-type level profiles of SAT are impacted by sex, admixed American ancestry, CMD traits, and cell-type level cis regulation in Mexicans, we generated a Mexican SAT single nucleus RNA sequencing cohort (n = 49). We performed cell-type level differential expression testing, weighted gene co-expression analysis, and cis-expression quantitative trait locus (eQTL) mappings. We then integrated genome-wide association study (GWAS) and Mexican population level data to assess partitioned polygenic risk for lipid outcomes and colocalization between SAT cell-type level cis-eQTL variants and lipid GWAS variants. RESULTS: First, we discovered and validated a sex-associated adipocyte subtype, overlapping an adipocyte co-expression network with 132 adipocyte function centered genes, including key triglyceride biosynthesis genes, GPAM, DGAT2, ACSL1, and LPL, that are differentially expressed
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
Evidence level
Early human evidence such as case series or small samples is exploring possible benefits.
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