Lipid metabolic adaptations of multi-donor mesenchymal stem cells during osteodifferentiation.
Bispo DSC., Graça ICR., Jesus CSH., Rodrigues JE., Goodfellow BJ., Oliveira MB.
Prospective Study, published in Biochim Biophys Acta Mol Cell Biol Lipids (2025) — summary generated from the PubMed abstract.
Early human evidence such as case series or small samples is exploring possible benefits.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Prospective Study
- Journal
- Biochim Biophys Acta Mol Cell Biol Lipids (2025)
- Country
- Netherlands
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 40783165
- DOI
- 10.1016/j.bbalip.2025.159680
Abstract (original English)
Mesenchymal stem cell (MSC) osteodifferentiation is accompanied by important lipid metabolic adaptations, which may reveal relevant biomarkers and potential osteoinductive species. However, high donor variability remains a challenge for biomarker identification. This work unveiled shared lipid features of human adipose-tissue MSC (hAMSC) for three independent donors, using an untargeted NMR spectroscopy methodology. The results showed that osteodifferentiation induced increases in esterified cholesterol preferentially enriched in shorter monounsaturated fatty acids (MUFA), and triacylglycerides containing longer fatty acids (FA), both consistent with increased lipid droplet formation in the cytosol. Membrane adaptations involved hydrolysis of phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn), possibly to allow subsequent polyunsaturated FA incorporation (to enhance membrane fluidity) and facilitate removal of peroxidized FA, while originating inorganic phosphate (Pi) for mineralization. PtdCho levels seem closely linked to the creatine-phosphocreatine axis, reflecting a shared contribution to Pi generation. MUFA also appeared to serve as preferential substrates for β-oxidation, apparently in association with antioxidative mechanisms. The above metabolic effects were indicative of a common pathway modulation in the three donors, with predicted upregulation of AL
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
Evidence level
Early human evidence such as case series or small samples is exploring possible benefits.
How we grade evidenceBrowse all related research
Filter the research library by this study's title keywords, author, or publication year.