Liporeinjection of Fat, Nanofat, and Stromal Vascular Fraction.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Autologous fat transfer has progressed from a volumetric filler to a regenerative cornerstone in modern facial plastic and reconstructive surgery. This article reviews the biological basis, technical refinements, and current processing systems that underpin facial fat grafting. Adipose tissue functions as both a biocompatible filler and a regenerative organ enriched with adipose-derived stem cells and stromal vascular fraction, driving angiogenesis, collagen remodeling, and skin rejuvenation. Commercial systems Puregraft, REVOLVE, Lipocube, and Tulip Nanofat are compared in terms of purification mechanisms, benefits, and clinical use. These closed sterile systems enhance safety, standardization, and predictability, bridging aesthetic artistry with regenerative science.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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