Liquid Crystal Monomers and Their Mixtures Alter Nuclear Receptor Signaling and Promote Adipogenesis In Vitro.
Heldman SM., Eccles KM., Kassotis CD.
Animal Study, published in Endocrinology (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Endocrinology (2025)
- Country
- United States
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 40994316
- DOI
- 10.1210/endocr/bqaf143
Abstract (original English)
Liquid crystal monomers (LCMs) are ubiquitous environmental contaminants released from electronic devices' liquid crystal display (LCD) panels, which have led to the contamination of food, breast milk, and serum. As the toxicity of individual LCMs, not to mention their myriad mixtures, is currently very poorly characterized, there is a crucial need for investigations into the health hazards posed by exposure. In this study, 10 nonfluorinated (NF) and fluorinated (F) LCMs and 3 fluorination-based LCM mixtures were screened for metabolism and endocrine-disrupting potential in vitro at exposure-relevant concentrations using adipogenesis assays and luciferase reporter gene assays. Both NF-LCMs, F-LCMs, and their mixtures were found to alter the transcriptional activity of one or more nuclear receptors. Notably, 6 LCMs and all LCM mixtures were able to antagonize the progesterone receptor, with several displaying non-monotonic concentration-response curves. Multiple LCMs and their mixtures also increased triglyceride accumulation in murine preadipocytes and human mesenchymal stem cells in a concentration-dependent manner. The concentration addition principle underestimated the adipogenic potencies of LCM mixtures when compared with those derived from benchmark concentration analyses of empirical adipogenesis assay results, suggesting synergistic interactions. While no mechanistic pa
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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