Live birth following multimodal therapy in a patient with asherman's syndrome, recurrent pregnancy loss, and polycystic ovarian syndrome: a case report and literature review

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background Improving the endometrial thickness (EMT) and pregnancy outcomes in cases of thin endometrium (TE) induced by severe intrauterine adhesion (IUA) is a significant clinical challenge. This report provides insight into a potential protocol for improving EMT and pregnancy outcomes in challenging cases of TE induced by IUA, especially for patients with concurrent polycystic ovary syndrome (PCOS) and experiencing recurrent spontaneous abortion (RSA). Case presentation We report the case of a 29-year-old woman with severe IUA, RSA, and PCOS, who experienced three spontaneous abortions. Copy number variations (CNV's) detection of fetal villi from the last abortion indicated Turner syndrome. Hysteroscopic adhesiolysis (HA) had been performed twice previously. She subsequently underwent superovulation using an antagonist regimen, resulting in oocyte retrieval and cryopreservation of four transplantable blastocysts after genetic testing. After three rounds of HA, the uterine cavity shape returned to normal. She then received two cycles of Femoston and/or estradiol valerate therapy combined with oral low-dose aspirin, vaginal sildenafil, pelvic floor electrical stimulation, and uterine perfusion platelet-rich plasma (PRP); however, the frozen embryo transfer (FET) was canceled as the EMT remained 4.9 mm and 3.9 mm. After three additional HA procedures and one hysteroscopy, the u

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

Browse all related research

Filter the research library by this study's title keywords, author, or publication year.