Localized delivery of Sr-doped mesoporous silica nanoparticles embedded in cryogels with adipose-derived stem cells promotes craniofacial bone regeneration in an osteoporotic rat model.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background Craniofacial bone defects are considered difficult to treat in osteoporosis individuals. Strontium (Sr) has been proven therapeutically beneficial for osteoporotic patients by multiple studies. Systemically administered, strontium may cause unfavorable adverse effects, but local application is promising. In this study, mesoporous silica nanoparticles (MSN) were used as nanocarriers of strontium, embedded into the hydrogel scaffold along with adipose-derived stem cells under local administration to evaluate its bone regenerating potential in osteoporotic rat model. Methods Mesoporous silica nanoparticles (MSN) and Sr-doped MSN (MSN-Sr) were synthesized using a cetyltrimethylammonium bromide-templated method with tetraethyl orthosilicate. Nanoparticles were characterized by inductively coupled plasma mass spectrometry, transmission electron microscope, dynamic light scattering nano-analyzer, and X-ray photoelectron spectrometer. Gelatin-based cryogels containing these nanoparticles were fabricated through crosslinking and freeze-drying, and evaluated for physicochemical properties, porosity, degradation, thermal stability, and swelling. Rat adipose-derived stem cells (ASCs) were seeded onto cryogels for osteogenic analysis by scanning electron microscope, field emission scanning electron microscope/energy dispersive spectrometer, and quantitative polymerase chain react

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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